Hyperhomocysteinemia in a Patient with Schizophrenia – A Case Report
DOI:
https://doi.org/10.30834/KJP.38.1.2025.520Keywords:
Hyperhomocysteinemia, Schizophrenia, Vitamin SupplementsAbstract
Hyperhomocysteinemia is a common metabolic disorder that is associated with mental disorders. Treatment with vitamin supplements was found to be beneficial in reducing elevated homocysteine levels. An 18-year-old male, presenting with a 1 ½ years history of schizophrenia, had elevated serum homocysteine. The elevated homocysteine level reached normal with vitamin supplements, and schizophrenic symptoms subsided with a relatively low dose of antipsychotics. Correcting metabolic errors such as hyperhomocysteinemia can result in significant improvement of associated psychotic symptoms.
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Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003 Mar;26(3):137-46.
Veeranki S, Gandhapudi SK, Tyagi SC. Interactions of hyperhomocysteinemia and T cell immunity in causation of hypertension. Canadian journal of physiology and pharmacology. 2016;95(3):239-46.
Goff DC, Bottiglieri T, Arning E, Shih V, Freudenreich O, Evins AE, Henderson DC, Baer L, Coyle J. Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry. 2004 Sep;161(9):1705-8.
Abbott MH, Folstein SE, Abbey H, Pyeritz RE. Psychiatric manifestations of homocystinuria due to cystathionine beta-synthase deficiency: prevalence, natural history, and relationship to neurologic impairment and vitamin B6-responsiveness. Am J Med Genet. 1987 Apr;26(4):959-69.
Narayan SK, Verman A, Kattimani S, Ananthanarayanan PH, Adithan C. Plasma homocysteine levels in depression and schizophrenia in South Indian Tamilian population. Indian J Psychiatry. 2014 Jan;56(1): 46-53.
Muntjewerff JW, van der Put N, Eskes T, Ellenbroek B, Steegers E, Blom H, Zitman F. Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Res. 2003 Nov 1;121(1):1-9.
Levine J, Stahl Z, Sela BA, Gavendo S, Ruderman V, Belmaker RH. Elevated homocysteine levels in young male patients with schizophrenia. Am J Psychiatry. 2002 Oct;159(10):1790-2.
Adler Nevo G, Meged S, Sela BA, Hanoch-Levi A, Hershko R, Weizman A. Homocysteine levels in adolescent schizophrenia patients. Eur Neuropsychopharmacol. 2006 Dec;16(8):588-91.
Misiak B, Frydecka D, Slezak R, Piotrowski P, Kiejna A. Elevated homocysteine level in first-episode schizophrenia patients--the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse. Metab Brain Dis. 2014 Sep;29(3):661-70.
Stahl Z, Belmaker RH, Friger M, Levine J. Nutritional and life style determinants of plasma homocysteine in schizophrenia patients. Eur Neuropsychopharmacol. 2005 May;15(3):291-5.
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Copyright (c) 2025 Gyanendra Rai, Anusree Nilavarayath , Anithakumari Ayirolimeethal, Padmini C (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
