Phenobarbital and Suicidality: A Case Report

How to Cite

Sahadevan, S., Jayarajan, R. N., Kezhukkut, J., Antony, T. P., & Sreekumar, D. (2017). Phenobarbital and Suicidality: A Case Report. Kerala Journal of Psychiatry , 30(1), 15-16.


Phenobarbital is widely-used in primary care for the treatment of epilepsy, headache and insomnia in India. There are certain scenarios in which its use must be monitored closely. We report a case wherein a lady was suffering from symptoms of mild depression following a stressor. After being prescribed Phenobarbital for headache and insomnia by a primary care physician, she developed suicidal ideation and made a suicide attempt. Clinicians should pick up possible appearance or worsening of depressive symptoms or emergence of suicidal ideation in patients on Phenobarbital and consider changing the treatment.


Mani KS, Rangan G, Srinivas HV, Sridharan VS, Subbakrishna DK. Epilepsy control with phenobarbital or phenytoin in rural south India: the Yelandur study. Lancet 2001; 357(9265):1316-20.

Nadkarni S, Devinsky O. Psychotropic effects of antiepileptic drugs. Epilepsy Curr 2005; 5(5):176-81.

Gureje O, Simon GE, Ustun TB, Goldberg DP. Somatization in cross-cultural perspective: a World Health Organization study in primary care. Am J Psychiatry 1997;154(7):989-95.

Kalinin VV. Suicidality and antiepileptic drugs. is there a link ? Drug Safety 2007; 30(2):123-42.

Brent DA, Crumrine PK, Varma R, Brown RV, Allan MJ. Phenobarbital treatment and major depressive disorder in children with epilepsy: a naturalistic follow-up. Pediatrics 1990; 85(6):1086-91.