Factors Influencing Relapse Among Alcohol Dependent Patients - A Mixed Method Study
DOI:
https://doi.org/10.30834/KJP.37.2.2024.469.Keywords:
Alcohol Dependence Syndrome, Reasons for Relapse, Qualitataive Study , Mixed Method, Co-morbid Tobacco Use, Borderline Personality DisorderAbstract
Background
Alcohol use disorders are chronic, and relapses occur due to neurobiological and psychosocial factors. This study was conducted to elicit the prevalence of psychiatric co-morbidities, severity of dependence, craving, and level of motivation in alcohol-dependent subjects who have relapsed and to elicit factors resulting in relapse using a mixed method.
Method
Eighty-two alcohol dependence syndrome patients (ADS) with a history of relapse were recruited after obtaining consent. A mixed method-concurrent parallel design was adopted. Mini-International neuropsychiatric interview (M.I.N.I), Penn Alcohol Craving Scale (PACS), Severity of Alcohol Dependence Questionnaire (SADQ), and Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) questionnaires were administered. Six in-depth interviews (IDI) and 5 focus group discussions (FGD) were conducted, and the data from the two phases were analyzed.
Results
The mean age of the participants was 44.45 years. 53.7 % had co-morbid tobacco use, 43.9 % had borderline personality disorder and 47.6% had mild dependency. 41.5 % had only moderate levels of motivation to quit. A significant association was obtained between the severity of dependence and craving (p= 0.016). Qualitative data identified 1) Drinking Motives, 2) Self-perception, 3) Misconceptions related to alcohol use, and 4) Social factors leading to relapse.
Conclusion
The study shows that co-morbid tobacco use and the presence of borderline personality disorders were higher in patients with relapse and that severe dependence was associated with higher craving. Motives related to usage, self-perception about alcohol use, misconceptions related to alcohol use, and social factors also led to relapse.
Funding: Self funded
Conflict of Interest: None
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References
Kumar P, Thadani A. Prevalence and correlates of relapse in adult male patients with alcohol dependence: a cross-sectional study conducted in a tertiary care hospital in Northern India. Int J Adv Med. 2022 Feb 23; 9(3):229–35. DOI: 10.18203/2349-3933.ijam20220383
World Health Organization. Global status report on alcohol and health and treatment of substance use disorders. 2024. https://iris.who.int/handle/10665/377960. (Accessed on September 10th)
Brandon TH, Vidrine JI, Litvin EB. Relapse and Relapse Prevention. Annu Rev Clin Psychol. 2007 Apr 27;3(Volume 3, 2007):257–84. DOI: 10.1146/annurev.clinpsy.3.022806.091455
Tao YJ, Hu L, He Y, Cao BR, Chen J, Ye YH, et al. A real-world study on clinical predictors of relapse after hospitalized detoxification in a Chinese cohort with alcohol dependence. PeerJ. 2019 Aug 28; 7:e7547. DOI: 10.7717/peerj.7547
Saunders B, Allsop S. Relapse: A psychological perspective. Br J Addict. 1987; 82(4):417–29. DOI: 10.1111/j.1360-0443.1987.tb01497.x
Barillot L, Chauvet C, Besnier M, Jaafari N, Solinas M, Chatard A. Effect of environmental enrichment on relapse rates in patients with severe alcohol use disorder: protocol for a randomized controlled trial. BMJ Open. 2023 May 12; 13(5):e069249. DOI: 10.1136/bmjopen-2022-069249
Stewart J. Psychological and neural mechanisms of relapse. Philos Trans R Soc B Biol Sci. 2008 Jul 18; 363(1507):3147–58. DOI: 10.1098/rstb.2008.0084
Ciccocioppo R, Hyytia P. The genetic of alcoholism: learning from 50 years of research. Addict Biol. 2006 Sep 1; 11(3–4):193–4. DOI: 10.1111/j.1369-1600.2006.00028.x
Feltenstein MW, See RE. The neurocircuitry of addiction: an overview. Br J Pharmacol. 2008; 154(2):261–74. DOI: 10.1038/bjp.2008.51
Marlatt GA, George WH. Relapse Prevention: Introduction and Overview of the Model. Br J Addict. 1984; 79(4):261–73. DOI: 10.1111/j.1360-0443.1984.tb00274.x
Larimer ME, Palmer RS, Marlatt GA. Relapse prevention. An overview of Marlatt’s cognitive-behavioral model. Alcohol Res Health J Natl Inst Alcohol Abuse Alcohol. 1999; 23(2):151–60. PMCID: PMC6760427
Mattoo SK, Chakrabarti S, Anjaiah M. Psychosocial factors associated with relapse in men with alcohol or opioid dependence. Indian J Med Res. 2009 Dec; 130(6):702. PMID: 20090130
Rampure R, Inbaraj LR, Elizabeth CG, Norman G. Factors Contributing to Alcohol Relapse in a Rural Population: Lessons from a Camp-Based De-Addiction Model from Rural Karnataka. Indian J Community Med. 2019 Oct-Dec; 44(4):307-312. DOI: 10.4103/ijcm.IJCM_321_18
Sliedrecht W, de Waart R, Witkiewitz K, Roozen HG. Alcohol use disorder relapse factors: A systematic review. Psychiatry Res. 2019 Aug; 278:97-115. doi: 10.1016/j.psychres.2019.05.038
Acharya M. Depression in Patients with Alcohol Dependence Syndrome in a Tertiary Care Center: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2021 Aug; 59(240):787–90. DOI: 10.31729/jnma.6967
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998; 59 Suppl 20:22-33. PMID: 9881538
Flannery BA, Volpicelli JR, Pettinati HM. Psychometric Properties of the Penn Alcohol Craving Scale. Alcohol Clin Exp Res. 1999; 23(8):1289–95. PMID: 10470970
Stockwell T, Murphy D, Hodgson R. The Severity of Alcohol Dependence Questionnaire: Its Use, Reliability and Validity. Br J Addict. 1983; 78(2):145–55. DOI: 10.1111/j.1360-0443.1983.tb05502.x
Miller WR, Tonigan JS. Assessing drinkers' motivation for change: the stages of change readiness and treatment eagerness scale (SOCRATES). Psychology of Addictive Behaviors. 2006; 10(2): 81–89. DOI:10.1037/0893-164X.10.2.81
Soman S, Vr A. The prevalence of psychiatric comorbidities and relapses in males treated for alcohol dependence syndrome – Prospective study from tertiary de-addiction care unit in Kerala, India. Eur Psychiatry. 2017 Apr; 41(S1):s879–s879. DOI:10.1016/j.eurpsy.2017.01.1774
Nagaich N, Radha S, Neeraj G, Sandeep N, Subhash N. Factors affecting remission and relapse in alcohol dependence can they really predict? J Liver Res Disord Ther. 2016; 2(3);78-81. DOI: 10.15406/jlrdt.2016.02.00028
Sau M, Mukherjee A, Manna N, Sanyal S. Sociodemographic and substance use correlates of repeated relapse among patients presenting for relapse treatment at an addiction treatment center in Kolkata, India. Afr Health Sci. 2013 Sep 6; 13(3):791–9. DOI: 10.4314/ahs.v13i3.39
Van Trieu N, Uthis P, Suktrakul S. Alcohol dependence and the psychological factors leading to a relapse: a hospital-based study in Vietnam. J Health Res. 2020 Jan 1; 35(2):118–31. DOI: 10.1108/JHR-07-2019-0157
Yazici AB, Bardakci MR. Factors associated with relapses in alcohol and substance use disorders. Eurasian J Med. 2023; 55(1):575-81. DOI: 10.5152/eurasianjmed.2023.23335
Stillman MA, Sutcliff J. Predictors of relapse in alcohol use disorder: Identifying individuals most vulnerable to relapse. Addict Subst Abuse 2020. 1(1): 3-8. DOI: 10.46439/addiction.1.002
Singh G, Husain Kazmi SS. A Qualitative Study of the Perception of Alcohol Dependence Syndrome Patients and Their Perspective towards Cognitive Therapy. J Adv Res Sci Soc Sci. 2023 Jan 11; 6(1):314–27. DOI: 10.46523/jarssc.06.01.28
Shorey RC, Stuart GL, Anderson S. Early maladaptive schemas among young adult male substance abusers: A comparison with a non-clinical group. J Subst Abuse Treat. 2013 May 1; 44(5):522–7. DOI: 10.1016/j.jsat.2012.12.001
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