Prevalence and characteristics of Thyroid dysfunction in patients with Depressive Disorders presenting to Tertiary care center- A cross-sectional study
Keywords:Depressive disorders, HAM-D, Thyroid dysfunction, TSH.
Background: Thyroid dysfunctions, hypothyroidism and hyperthyroidism, can lead to mood disorders like depression and mania. Conversely, depressive disorders are associated with subtle variations in thyroid hormone levels. Objectives: The objective of the study was to examine the prevalence and characteristics of thyroid dysfunction in patients with Depressive disorders. Methodology: A cross-sectional study was conducted on patients diagnosed with depressive disorders who presented to outpatient and inpatient setting in the psychiatry department. Consecutive sampling method was used till the calculated sample size of 82 patients was reached. Diagnosis of depressive disorder was done as per the International Classification of Diseases, 10th revision (ICD-10). Hamilton depression rating scale (HAM-D) was administered to assess the severity of depressive symptoms. Thyroid Dysfunction was diagnosed based on the morning (8 AM) serum levels of T3, T4 and TSH levels. Data analysis was done using statistical package for the social sciences (version 24), and results were presented as mean and percentages. Results: Among 82 patients with depression, the prevalence of thyroid dysfunction was 15% (12), and subclinical hypothyroidism was the most common type with prevalence of 11% (9), followed by hypothyroidism. There was no significant association between the severity of depressive episode and the type of thyroid dysfunction (x2-14.208, df-9, p-.115). Conclusion: Prevalence of thyroid dysfunction is higher in depressive disorders. Regular monitoring of Thyroid functions tests should be considered during follow up to prevent relapse of symptoms.
Rihmer Z, Angst A, Sadock BJ, Sadock VA. Mood Disorders: Epidemiology. Comprehensive textbook of psychiatry. 10th edn. Baltimore: Lippincott Williams ans Wilkins. 2017.
Charnsi C, Pilakanta S.Prevalence of Thyroid Dysfunction and Its Relationship with the severity of Major Depressive Disorder. Ann Psychiatry Ment Health 2016; 4(6): 1081.
Bahls SC, Carvalho, GA. The relationship between thyroid function and depression: a review. RevistaBrasileira de Psiquiatria 2004;26 (1), 41-49. doi: 10.1590 / s1516-44462004000100012.
Esposito S, Prange, AJ, Golden R. The Thyroid axis and mood disorders: overview and future prospects. Psychopharmacology bulletin 1997;33:205-17.
Gold MS, Pottash AL, Extein I. Hypothyroidism and depression. Evidence from complete thyroid function evaluation. JAMA 1981;245(19):1919-22.
Ojha SP, Dhungana S, Chapagain M, Tulchan P: Association of thyroid dysfunction with depression in a teaching hospital. J Nepal Health Recounc 2013;11: 30-34.
Thapa A, Karki M, Thapa A. Prevalence of Thyroid Dysfunction and its Relationship with Severity of Depression among Patients of Depression Attending Tertiary Hospital. JCMS Nepal 2020; 16(3):128-32.
Olden M, Rosenfeld B, Pessin H, Breitbart W. Measuring depression at the end of life: is the Hamilton Depression Rating Scale a valid instrument? Assessment. 2009 Mar;16(1):43-54. doi: 10.1177/1073191108320415. Epub 2008 Aug 1. PMID: 18676960; PMCID: PMC3987780.
Stipcevi? T, Pivac N, Kozari?-Kovaci? D, Mück-Seler D. Thyroid activity in patients with major depression. Coll Antropol. 2008 Sep;32(3):973-6. PMID: 18982776.
Lokesh J, Harish A. A study of correlation between Depression and Hypothyroidism in female patients 2013; 16: 1–5.
Dayan CM, Panicker V. Hypothyroidism and Depression. European Thyroid Journal 2013;2(3): 168–179.
Stone MB, Wallace RB. Medicare Coverage of Routine Screening for Thyroid Dysfunction. Institute of Medicine (US) Committee on Medicare Coverage of Routine Thyroid Screening National Academies Press Washington (US); 2003.
Kafle B, Khadka B, Tiwari ML. Prevalence of Thyroid Dysfunction Among Depression Patients in a Tertiary Care Centre. JNMA J Nepal Med Assoc. 2020 Sep 27;58(229):654-658.
How to Cite
Copyright (c) 2022 Dr Fakirappa B Ganiger, Dr Safeekh AT, Dr Somashekhar Bijjal, Dr Manisha Sharma (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.