Anxiety, depression and quality of life in breast cancer patients undergoing chemotherapy in a tertiary care centre- a cross-sectional study

Authors

  • Nimmy Susan Abraham Junior Resident, Department of Psychiatry, Pushpagiri Institute of Medical Sciences & Research Centre, Thiruvalla
  • Roy Abraham Kallivayalil Professor & Head, Department of Psychiatry, Pushpagiri Institute of Medical Sciences & Research Centre, Thiruvalla

DOI:

https://doi.org/10.30834/KJP.34.2.2021.286

Keywords:

anxiety, depression, quality of life, breast cancer, chemotherapy

Abstract

Background: Breast cancer is the commonest cancer among women worldwide. The diagnosis and treatment of breast cancer are strongly associated with anxiety and depression, which negatively affects the patient's quality of life (QOL). We aimed to study the prevalence of anxiety and depression in breast cancer patients undergoing chemotherapy and their quality of life. Methods: This cross-sectional study included 30 women aged 18-65 years diagnosed with breast cancer and undergoing chemotherapy in a tertiary care centre in Kerala, India. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). QOL and its domains were assessed using the WHOQOL?BREF. Results: The mean age of women in the study was 53.57±7.33 years. Of the 30 patients, the prevalence of anxiety and depression was 16.7% and 20.0%, respectively. The severity of anxiety was mild, and among patients with depression, 3.3% had moderate depression. In the domains of QOL, the physical domain score was minimal, while the domain of the social relation had a maximum score. The physical domain of QOL was significantly associated with chemotherapy-related hair loss and mouth sores, psychological domain with a family history of psychiatric illness, chemotherapy-related nausea/vomiting and mouth sores. Occupation and total monthly income were associated with the environment domain and postsurgical status with the social relations domain. Conclusion: Anxiety and depression were found in breast cancer patients undergoing chemotherapy, and the overall QOL was not affected by anxiety or depression.

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References

https://ncdirindia.org/All_Reports/Report_2020/default.aspx

Jones HA, Antonini N, Hart G, Fourquet A, Hoogenraad WJ, Horiot JC, Poortmans PM, Jager JJ, Van den Bogaert W, Bartelink H. Significance of margins of excision on breast cancer recurrence (on behalf of the EORTC Radiotherapy, Breast Cancer Groups). EJC Supplements. 2004;3(2):147.

Palumbo MO, Kavan P, Miller Jr WH, Panasci L, Assouline S, Johnson N, Cohen V, Patenaude F, Pollak M, Jagoe RT, Batist G. Systemic cancer therapy: achievements and challenges that lie ahead Front.

Reich M, Lesur A, Perdrizet-Chevallier C. Depression, quality of life and breast cancer: a review of the literature. Breast cancer research and treatment. 2008 Jul 1;110(1):9-17.

Kennedy F, Harcourt D, Rumsey N, White P. The psychosocial impact of ductal carcinoma in situ (DCIS): a longitudinal prospective study. The Breast. 2010 Oct 1;19(5):382-7.

Pandey M, Sarita GP, Devi N, Thomas BC, Hussain BM, Krishnan R. Distress, anxiety, and depression in cancer patients undergoing chemotherapy. World Journal of Surgical Oncology. 2006 Dec 1;4(1):68.

Andersen KG, Christensen KB, Kehlet H, Bidstup PE. The effect of pain on physical functioning after breast cancer treatment. The Clinical journal of pain. 2015 Sep 1;31(9):794-802.

Ng CG, Mohamed S, See MH, Harun F, Dahlui M, Sulaiman AH, Zainal NZ, Taib NA, MyBCC Study group. Anxiety, depression, perceived social support and quality of life in Malaysian breast cancer patients: a 1-year prospective study. Health and quality of life outcomes. 2015 Dec 1;13(1):205.

Liao MN, Chen SC, Chen SC, Lin YC, Chen MF, Wang CH, Hsu YH, Hung HC, Jane SW. Change and predictors of symptom distress in breast cancer patients following the first 4 months after diagnosis. Journal of the Formosan Medical Association. 2015 Mar 1;114(3):246-53.

Charalambous A, Kaite CP, Charalambous M, Tistsi T, Kouta C. The effects on anxiety and quality of life of breast cancer patients following completion of the first cycle of chemotherapy. SAGE Open Medicine. 2017 Jun 27;5:2050312117717507.

Sadoughi M, Salehi ZM. The relationship between anxiety, depression, and quality of life among women with breast cancer. International Journal of Academic Research in Psychology. 2017;4(1):11-9.

Nikbakhsh N, Moudi S, Abbasian S, Khafri S. Prevalence of depression and anxiety among cancer patients. Caspian journal of internal medicine. 2014;5(3):167.

ABUSE PO. Programme On Mental Health. Retrieved from. 1997.

Lyraraki E, Malliarou M, Bamidis P, Sarafis P. Depression, Anxiety and Quality of Life of Women with Breast Cancer. International Research Journal of Oncology. 2018 Jul 17:1-2.

Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica. 1983 Jun;67(6):361-70.

Sreedevi A, Cherkil S, Kuttikattu DS, Kamalamma L, Oldenburg B. Validation of WHOQOL-BREF in Malayalam and determinants of quality of life among people with type 2 diabetes in Kerala, India. Asia Pacific Journal of Public Health. 2016 Jan;28(1_suppl):62S-9S.

Mehnert A, Koch U. Psychological comorbidity and health-related quality of life and its association with awareness, utilization, and need for psychosocial support in a cancer register-based sample of long-term breast cancer survivors. Journal of psychosomatic research. 2008 Apr 1;64(4):383-91.

Deshields T, Tibbs T, Fan MY, Taylor M. Differences in patterns of depression after treatment for breast cancer. Psycho?Oncology: Journal of the Psychological, Social and Behavioral Dimensions of Cancer. 2006 May;15(5):398-406.

Burgess C, Cornelius V, Love S, Graham J, Richards M, Ramirez A. Depression and anxiety in women with early breast cancer: five year observational cohort study. BMJ. 2005 Mar 24;330(7493):702.

Srivastava V, Ansari MA, Kumar A, Shah AG, Meena RK, Sevach P, Singh OP. Study of anxiety and depression among breast cancer patients from North India. Clinical Psychiatry. 2016;2(1):4.

Purkayastha D, Venkateswaran C, Nayar K, Unnikrishnan UG. Prevalence of depression in breast cancer patients and its association with their quality of life: A cross-sectional observational study. Indian journal of palliative care. 2017 Jul;23(3):268.

Yusof S, Zakaria FN, Hashim NK, Dasiman R. Depressive symptoms among cancer patients undergoing chemotherapy. Procedia-Social and Behavioral Sciences. 2016 Oct 31;234:185-92.

Tsaras K, Papathanasiou IV, Mitsi D, Veneti A, Kelesi M, Zyga S, Fradelos EC. Assessment of depression and anxiety in breast cancer patients: prevalence and associated factors. Asian Pacific journal of cancer prevention: APJCP. 2018;19(6):1661.

Broeckel JA, Jacobsen PB, Horton J, Balducci L, Lyman GH. Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer. Journal of Clinical Oncology. 1998 May;16(5):1689-96.

Hassan MR, Shah SA, Ghazi HF, Mujar NM, Samsuri MF, Baharom N. Anxiety and depression among breast cancer patients in an urban setting in Malaysia. Asian Pacific Journal of Cancer Prevention. 2015;16(9):4031-5.

McFarland DC, Shaffer KM, Tiersten A, Holland J. Physical symptom burden and its association with distress, anxiety, and depression in breast cancer. Psychosomatics. 2018 Sep 1;59(5):464-71.

Montazeri A, Vahdaninia M, Harirchi I, Ebrahimi M, Khaleghi F, Jarvandi S. Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study. BMC Cancer. 2008 Dec 1;8(1):330.

Akel R, El Darsa H, Anouti B, Mukherji D, Temraz S, Raslan R, Tfayli A, Assi H. Anxiety, depression and quality of life in breast cancer patients in the levant. Asian Pacific journal of cancer prevention: APJCP. 2017;18(10):2809.

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Published

31-10-2021

How to Cite

Abraham, N. S. ., and R. A. . Kallivayalil. “Anxiety, Depression and Quality of Life in Breast Cancer Patients Undergoing Chemotherapy in a Tertiary Care Centre- a Cross-Sectional Study”. Kerala Journal of Psychiatry, vol. 34, no. 2, Oct. 2021, pp. 127-34, doi:10.30834/KJP.34.2.2021.286.

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Section

Research Report