Darier's disease and Schizophrenia- A case report
Keywords:Darier's disease, Schizophrenia
Darier's disease is a rare autosomal dominant genodermatosis. There is a specific mutation in the ATP2A2 gene on chromosome 12q. Several neuropsychiatric manifestations have been described in association with Darier's disease. Most reports have come from western populations, with limited reports of Darier's disease and its neuropsychiatric associations among Asian people, although the demographic and clinical profiles are comparable. We present a case of 38 year old female from Kerala with Darier's disease presenting with schizophrenia spectrum disorder. Her first degree relatives have schizophrenia-like psychosis and dermatological manifestations suggestive of Darier's disease.
Tavadia S, Mortimer E, Munro CS. Genetic epidemiology of Darier's disease: a population study in the west of Scotland. Br J Dermatol. 2002 Jan;146(1):107–9.
Svendsen IB, Albrectsen B. The prevalence of dyskeratosis follicularis (Darier's disease) in Denmark: an investigation of the heredity in 22 families. Acta Derm Venereol. 1959;39:256–69.
Burge SM, Wilkinson JD. Darier-White disease: a review of the clinical features in 163 patients. J Am Acad Dermatol. 1992 Jul;27(1):40–50.
Sakuntabhai A, Ruiz-Perez V, Carter S, Jacobsen N, Burge S, Monk S, et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet. 1999 Mar;21(3):271–7.
Mutational analysis of the ATP2A2 gene in two Darier disease families with intrafamilial variability - Onozuka - 2004 - British Journal of Dermatology - Wiley Online Library [Internet]. [cited 2021 May 3]. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0007-0963.2004.05868.x
Sehgal VN, Srivastava G. Darier's (Darier-White) disease/keratosis follicularis. Int J Dermatol. 2005 Mar;44(3):184–92.
Getzler NA, Flint A. Keratosis follicularis. A study of one family. Arch Dermatol. 1966 May;93(5):545–9.
Medansky RS. WOLOSHIN AA: Darier's disease. An evaluation of its neuropsychiatric component. Arch Dermatol. 1961 Sep;84:482–4.
Craddock NJ, Owen MJ, Burge S, Kurian B, Thomas P, McGuffin P. Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis). Br J Psychiatry. 1994 Mar;164(3):355–8.
Wang S-L, Yang S-F, Chen C-C, Tsai P-T, Chai C-Y. Darier's disease associated with bipolar affective disorder: a case report. Kaohsiung J Med Sci. 2002 Dec;18(12):622–6.
Denicoff KD, Lehman ZA, Rubinow DR, Schmidt PJ, Peck GL. Suicidal ideation in Darier's disease. J Am Acad Dermatol. 1990 Feb;22(2 Pt 1):196–8.
Hellwig B, Hesslinger B, Walden J. Darier's Disease and psychosis. Psychiatry Res. 1996 Oct 16;64(3):205–7.
O'Malley MP, Bassett AS, Honer WG, Kennedy JL, King N, Berg D. Linkage analysis between schizophrenia and the Darier's disease region on 12q. Psychiatr Genet. 1996;6(4):187–90.
Jacobsen NJ, Lyons I, Hoogendoorn B, Burge S, Kwok PY, O'Donovan MC, et al. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Hum Mol Genet. 1999 Sep;8(9):1631–6.
Jones I, Jacobsen N, Green EK, Elvidge GP, Owen MJ, Craddock N. Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's disease. Mol Psychiatry. 2002;7(4):424–7.
Godi A. Darier disease. A review of pathophysiological mechanisms. R E V E W. 2003;12(4):8.
Goh BK, Ang P, Goh CL. Darier's disease in Singapore. Br J Dermatol. 2005 Feb;152(2):284–8.
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