Diabetic Ketoacidosis Associated with Quetiapine Treatment: A Case Report


  • Badr Ratnakaran Holy Cross Hospital and Mental Health Centre, Koovappally, Kottayam, Kerala. Pin-686518
  • S Sethulakshmi


Atypical antipsychotics are known for their metabolic side effects and there have been reports of them precipitating diabetic ketoacidosis which can be even fatal. We present a case of quetiapine induced diabetic ketoacidosis in a case of depression during inpatient treatment, highlighting the need to monitor not only metabolic side effects but also fatal complications like diabetic ketoacidosis.

Author Biography

Badr Ratnakaran, Holy Cross Hospital and Mental Health Centre, Koovappally, Kottayam, Kerala. Pin-686518

Consultant Psychiatrist


Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs 2005; 19 Suppl 1:1–93.

Jin H, Meyer JM, Jeste DV. Phenomenology of and Risk Factors for New-Onset Diabetes Mellitus and Diabetic Ketoacidosis Associated with Atypical Antipsychotics: An Analysis of 45 Published Cases. Ann Clin Psychiatry 2002; 14:59–64.

American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists, North American Association for the Study of Obesity. Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes. Diabetes Care 2004; 27:596–601.

Ely SF, Neitzel AR, Gill JR. Fatal diabetic ketoacidosis and antipsychotic medication. J Forensic Sci 2013; 58:398–403.

McIntyre A, Gendron A, McIntyre A. Quetiapine adjunct to selective serotonin reuptake inhibitors or venlafaxine in patients with major depression, comorbid anxiety, and residual depressive symptoms: a randomized, placebo-controlled pilot study. Depress Anxiety 2007; 24:487–94.

Koller EA, Weber J, Doraiswamy PM, Schneider BS. A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus. J Clin Psychiatry 2004; 65:857–63.

Rashid J, Starer PJ, Javaid S. Pancreatitis and Diabetic Ketoacidosis with Quetiapine Use. Psychiatry Edgmont 2009; 6:34–7.

Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic Crises in Adult Patients With Diabetes. Diabetes Care 2009;32: 1335–43.

Nasrallah HA. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry 2007; 13:27–35.

Ardizzone TD, Bradley RJ, Freeman AM, Dwyer DS. Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine. Brain Res 2001; 923:82–90.




How to Cite

Ratnakaran, B., & Sethulakshmi, S. (2015). Diabetic Ketoacidosis Associated with Quetiapine Treatment: A Case Report. Kerala Journal of Psychiatry, 28(1), 34–37. Retrieved from https://kjponline.com/index.php/kjp/article/view/11